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Programme Schedule - ProUPS 2025 *

DAY 01 (3rd February 2025)

Time Schedule
9:30 - 11:00 am Welcome & Registration (Breakfast)

INAUGURAL FUNCTION

11.00 - 1.00 pm Welcome address by Meeting Secretary (Dr. Indrajit Sahu, SRMIST) A short video clip about SRM-IST
--Lighting of the lamp--
Special address: Prof. LS Shashidhara, Director, National Centre of Biological Sciences, Bangalore
Inaugural address: Lt Col Dr. A Ravi Kumar, Pro-Vice Chancellor, SRM Medical College & Hospital
Keynote address: C. Muthamizhchelvan, Vice Chancellor, SRM-IST University, Chennai
Presidential address: Dr. P Satyanarayan, President, SRM-IST University, Chennai
A short video clip about Prof. Aaron Ciechanover (8 min)
Felicitation to Prof. Aaron Ciechanover
Speech by Prof. Aaron Ciechanover (20 min)
Title: The discovery of the ubiquitin system – how embarrassingly simple it was.
Vote of thanks: Dr. Rajiv Janardhanan (Conference Chairperson)
1:00 - 2.00 pm Networking and Lunch
Session-1 UBIQUITIN SIGNALING
Chair- Dr. Ranabir Das NCBS Bangalore
2.00 - 2.30 pm Invited Talk - 1
Prof. David Komander, WEHI, Australia
Title: Crossing Codes – at the intersection between ubiquitin and sugars
2.30 - 3.00 pm Invited Talk - 2
Prof. Yogesh Kulathu,MRC-PPU, University of Dundee
Title: Regulation of cellular stress responses by branched ubiquitin signalling.
3.00 - 3.30 pm Invited Talk - 3
Dr. Maddika Subba Reddy, CDFD Hyderabad
Title:Canonical vs non-canonical ubiquitination: control of protein fate.
3.30 - 4.00 pm Short talks (10 minutes) by young Researchers (On the 3 themes)
- Ubiquitin signalling
- Ubiquitination, Deubiquitination & Ub-like modifications
- Proteostasis & Protein degradation pathways
Selected Talk – 1: TBA
Selected Talk - 2: TBA
Selected Talk - 3: TBA
4.00 - 4:30 pm Networking and Coffee break (Poster installation)
Session-2 Ubiquitin signaling
Chair- Dr. Muralidhara Rao Maradana, SRMIST, Chennai, India
4.30 - 5.00 pm Invited Talk - 4
Prof. Kazuhiro Iwai,Kyoto University, Japan
Title: Ubiquitin in signaling: a tale of atypical linear ubiquitin chains
4.30 - 5.00 pm Invited Talk - 5
Dr. Parul Mishra,University of Hyderabad, India
Title: Decoding the ubiquitin code complexity: From cellular harmony to disease phenotype
5.30 - 6.00 pm Invited Talk - 6
Prof. Ashraf Brik,Technion-IIT, Haifa, Israel
Title: NNovel approaches to modulate ubiquitin signaling: Chemistry and Biology
6.00 - 6.20 pm 4 Flash-talks of 3 minutes each from young-researchers
Themes : Ubiquitin signalling; Ubiquitination, Deubiquitination & Ub-like modifications; Proteostasis & Protein degradation pathways.
6.20 - 8.00 pm Networking & POSTER SESSION – 1
(Coordinators: Dr. Dhruv Nandi & Dr. A. Preethika)
Themes : Ubiquitin signalling; Ubiquitination, Deubiquitination & Ub-like modifications; Proteostasis & Protein degradation pathways.
7:30 - 9:30 pm Dinner

DAY 02 (4th February 2025)

Time Schedule
8.00 - 9.00 am Breakfast
Session-3 Structure & Function of UPS
CHAIR- Dr. Senthil Thangaraj, SRMIST, Chennai, India
9.00 - 9.30 am Invited Talk - 7
Prof. Christopher Lima,MSKCC, New York US
Title: Capturing conformational transitions in the ubiquitin conjugation cascade
9.30 - 10.00 am Invited Talk - 8
Dr. Atul Kumar, IISER, Bhopal
Title: : New insights into the activation mechanism of Parkin E3-ligase
10.00- 11.00 am Plenary Lecture by Noble Laureate
Prof. Aaron Ciechanover, Technion-IIT, Haifa, Israel
Title: Control of nucleo-cytosolic proteasomal translocation as a platform for anti-cancer drug development.
11.00 - 11.30 am Networking and Coffee break
Session-4 Structure & Function of UPS
CHAIR-Dr. Shiny PJ, SRMIST, Chennai, India
11.30 - 12.00 pm Invited Talk - 9
Dr. Sonja Lorenz,MPI Gottingen
Title: Regulatory concepts in HECT-type ubiquitin ligases
12:00 - 12.30 pm Invited Talk - 10,
Dr. Ranabir Das, NCBS, Bangalore
Title: NMR-detected protein dynamics is present at the centre of host-pathogen interactions
12.30 - 1.00 pm Short talks (10 min) by young Researchers- - (On the 3 themes) - Structure & function of Ubiquitin-Proteasome System (UPS)
- UPS role in Human health & diseases
- UPS in Cancer & Neurodegeneration
Selected Talk - 4: TBA
Selected Talk - 5: TBA
Selected Talk - 6: TBA
1:00 - 2.00 pm Networking and Lunch (Poster installation)
Session-5 Proteostasis & Protein degradation pathways
Chair- Dr. Madhumitha Haridoss, SRMIST, Chennai, India
2.00 - 2.30 pm Invited Talk - 11
Dr. Carlos Castaneda,Syracuse University, New York, USA
Title: Role of ubiquitin-binding shuttle protein phase transitions in protein quality control
2:30 - 3.00 pm Invited Talk - 12
Dr. Shravan Kumar Mishra,IISER Mohali
Title: Nucleus-to-Golgi signalling through Sde2-specific deubiquitination enzymes
3:00 - 3.30 pm 6 Flash-talks of 3 minutes each from young-researchers
Themes : Structure & function of Ubiquitin-Proteasome System (UPS); UPS role in Human health & diseases; UPS in Cancer & Neurodegeneration;
3.30 - 4:00 pm Networking and Coffee break
3:30 - 5.00 pm POSTER SESSION – 2
(Coordinators: Dr. Piyush Agrawal & Dr. P. Venketaraman)
Themes : Structure & function of Ubiquitin-Proteasome System (UPS); UPS role in Human health & diseases; UPS in cancer & neurodegeneration.
Session-6 Drug discovery in UPS
Chair- Dr. Gisha Sivan, SRMIST, Chennai, India
5.00 - 5:30 pm Invited Talk - 13
Prof. T. P. Singh,AIIMS, New Delhi, India
Title: Structure-based rational approaches for new drug discovery
5.30 - 6:00 pm Short talks (10 min) by young Researchers- - (On the 3 themes)
- Autophagy, Mitophagy & ERAD pathways
- Targeted Protein degradation & PROTACs
- Drug discovery in UPS
Selected Talk - 7: TBA
Selected Talk - 8: TBA
Selected Talk - 9: TBA
6.00 - 7.00 pm Panel discussion: “How far are we towards drug discoveries targeting the UPS”.
Moderator : Dr. Prasanna Venkatraman, Dy Director, ACTREC, Mumbai
Panelists :
Prof. Aaron Ciechanover, Technion-IIT, Haifa, Israel
Prof. T. P. Singh, AIIMS, New Delhi, India
Prof. David Komander, WEHI, Australia
Prof. Christopher Lima, MSKCC, New York US
7.00 - 8.00 pm Cultural Programme
8:00 - 10:00 pm Dinner/Gala Dinner & Networking

DAY 03 (5th February 2025)

Time Schedule
8.00 - 9.00 am Breakfast (Poster installation)
Session-7 UPS in human health & diseases
CHAIR- Dr. Indrajit Sahu, SRMIST, Chennai, India
9.00 - 9.30 am Invited Talk - 14
Prof. Michael GlickmanTechnion-IIT, Haifa, Israel
Title: A cryptic ligase activity and ubiquitin signaling disruption in Alzheimer's disease: Mechanistic insights and implications
9.30 - 10.00 am Invited Talk - 15
Dr. Prasanna Venkatraman, Dr. Prasanna Venkatraman
Title: Proteasomal Assembly Chaperones in and out of proteostatsis
10.00- 10.30 am Invited Talk - 16
Dr. Manas Santra,NCCS, Pune
Title: FBXO31 controls DNA damage repair processes by monitoring proteostasis of proteins
10.30 - 11.00 am 6 Flash-talks of 3 minutes each from young-researchers

Themes: Autophagy, Mitophagy & ERAD pathways; Targeted protein degradation & PROTACs; Drug discovery in UPS.
11.00 - 12.30 am POSTER SESSION -8
(Coordinators: Dr. Subhashis Pal & Dr. Sundaresan S)
Themes : Autophagy/ Mitophagy & ERAD pathways Targeted protein degradation & PROTACs Drug discovery in UPS
12.30 - 1.30 pm Networking and Lunch
Session-8 Autophagy, Mitophagy & ERAD pathways
CHAIR- Dr. Raji Lenin, SRMIST, Chennai, India
1.30 - 2.00 pm Invited Talk - 17
Prof. Ivan Dikic,IBC Frankfurt, Germany
Title: Ubiquitin and Autophagy networks in regulation of ER- remodelling
2.00 - 2.30 pm Invited Talk - 18
Dr. Santosh Chouhan,CCMB, Hyderabad
Title: RNA-binding E3-ubiquitin ligase in Cancer and Immunity
2.30 - 3.00 pm Invited Talk - 19
Prof. Helen Walden,University of Glasgow
Title: : Targeting Parkin substrates
3.00 - 3.30 pm Oral, Poster & Travel awards announcement by the organizing members - TBA
Concluding Remarks & Vote of Thanks by Meeting Secretary (Dr. Indrajit Sahu & Dr. Raji Lenin)
3.30 pm onwards Goodbye…
4.00 pm Onwards Visit to Mahabalipuram (For Invited Speakers only)

* This schedule is not the final one, details of the programme may be changed. Please stay tuned for the final Programme schedule by the end of October 2024.